We study the molecular logic of adhesion GPCRs in health and disease.
We investigate molecular actors that belong to the class of adhesion-type G protein-coupled receptors. These molecules form a large group of surface receptors that constitute natural chimeras between an extracellular adhesion moiety and a transmembrane metabotropic signalling unit.
We have discovered that specific adhesion GPCRs control developmental processes such as planar cell polarity and cell migration, and have contributed to the understanding how adhesion and signalling is functionally combined within these mysterious surface receptors.
Recently we have defined adhesion GPCRs as mechanoreceptors suggesting a novel scientific angle to study and understand their physiological profiles in a multitude of tissues and cell types including neurons, glia, muscle, vasculature and the heart.
We are also harnessing our knowledge to understand how adhesion GPCR dysfunction results in disease with focus on cancers and neuropsychiatric disorders. To this end we closely collaborate with clinician scientists and human geneticists to identify adhesion GPCR gene variants that cause human ailments.
We study these phenomena using the fruitfly Drosophila melanogaster and the the roundworm Caenorhabditis elegans and employ their vast genetic, molecular biological, imaging and functional toolkits. This is complemented by in vitro and in silico approaches encompassing molecular modifications through genetic code expansion and bioorthogonal click chemistry, pharmacological and cell biological assays, super-resolution and atomic force microscopy, structural biology, and molecular dynamics simulations.
Fabian Pohl, PhD
鍾炫坤 (Yin 'Alex' Chung), MSc
Dmitrij Ljaschenko, PhD
Anne Dahse, MSc
Paula Beckmann, MSc
Tobias Langenhan, MD, DPhil
Head of Department
Fernando Vieira Contreras, MSc
Nicole Scholz, PhD
Marek Körner, MSc
Beatriz Blanco-Redondo, PhD
Stephanie Häfner, PhD
Anne Bormann, MSc
Genevieve Auger, MSc
Ina Brauer, MSc
PhD Student (2018-2022)
Mathias Böhme, PhD
Group leader (2021-2023)
Marina Bigl, PhD
Group Leader (2016-2021)
Steffen Altrichter, PhD
PhD Student (2015-2020)
Matthias Nieberler, MD
MD Student (2013-2018)
Student assistant (2022-2023)
MSc Student, Biology (2020-2021)
MSc Student, Molecular Life Sciences @ University of Lübeck (2018)
Mareike Hemberger, MSc
MSc and PhD Student, Physics (2018-2022)
Sophia Schmidt, BSc
Student assistant (2020-2022)
BSc and MSc Student, Biochemistry (2018-2020)
Erasmus Student, Cardiff University (2017-2018)
MD Student, Medicine (2019-2023)
Carlo Eberlein, MSc
MSc student (2020-2021)
Robert Wieduwild, PhD
Group Leader (2018-2020)
管崇霖 (Chonglin Guan), PhD
PhD Student (2012-2017)
We are eager to take on new lab members at different stages in their career starting from lab interns, students striving for their bachelor and master projects, M.D. and Ph.D. candidates, as well as postdoctoral researchers.
If you are interested in joining our research party get in touch at
tobi ÄT langenhan-lab.org with your motivation, project ideas and transcripts.
READY FOR A FUN AND
AMBITIOUS PHD PROJECT?
Several fixed-term for 3 years PhD positions are open at the Langenhan Lab based at the University of Leipzig. The successful candidates will work at the interface between molecular pharmacology, physiology and biophysics in a project of the Rudolf Schönheimer Institute for Biochemistry.
The projects concern the investigation of novel class of surface receptor molecules that function as mechanosensors and are markers of cancer progression.
Central questions concern the fundamental physiological tasks, pharmacological principles and viscoelastic properties of these receptors and their expressing cells and tissues. The main objective is the determination how these receptors’ activation and signaling mechanism is implemented at the molecular and cellular scale. The projects will rest on the close collaboration between biomedical researchers, structural biologists and physicists. The experimental measurements will be facilitated by in-house theoretical and experimental support.
The successful candidates will establish structure-function studies and pharmacological signaling assays of receptor activity, and combine those with biophysical measurements, genetic, biofinformatical and physiological assays using Drosophila melanogaster as an in vivo model for adhesion GPCR signaling.
Who are you?
The candidates should have a MSc. degree in physics, material science, biology or related fields, be fluent in English and have solid background in physics or molecular biology. Experience with the investigation of biomolecules with physical methods (e.g. AFM-FS, magnetic or optical tweezers), molecular biology or Drosophila is beneficial but not mandatory.
POSTDOCTORAL RESEARCH ASSOCIATE
OR GROUP LEADER POSITION
Applications are sought from strong candidates working in any area of biomedicine that complements or builds upon existing research strengths in the department. This search is open, but preference is given to those applicants with experience in neurobiology, molecular pharmacology or biochemistry holding or seeking their own post-doctoral fellowship.
This is for you to define. We'll help and advise you to get you started,
build up your own team, procure funding and excel with your research ideas.
Who are you?
Candidates must hold a Doctorate in a biological subject (ideally medicine, biology, bioinformatics, or biochemistry). Candidates are given the opportunity to establish their own research program, and assistance will be available to attract the necessary funding for the successful applicant.
Who are we?
The PhD students will have access to state-of-the-art laboratories, which are located at the Institute of Biochemistry and partner institutions in Leipzig. The international and interdisciplinary environment at the department provides an excellent infrastructure allowing dynamic scientific exchange across the traditional disciplines. The lab has also a central role in the German (www.adhesiongpcr.de) and international adhesion GPCR communities (www.adhesiongpcr.org) and successful candidates will gain immediate access to a young yet rapidly emerging field in biomedicine with substantial long-term career potential.
Leipzig is a pretty sassy place to be at in Germany, of not the trendiest ... say not only we but also the New York Times, The Guardian, Der Spiegel, and others.
In addition, Leipzig University is an equal opportunity employer and is committed to increase the proportion of women in academia. Consequently, we actively encourage applications by female colleagues. Female candidates with equivalent qualifications and academic achievements will be preferentially considered within the framework of the legal possibilities. We also welcome applications from candidates with severe disabilities. Disabled candidates with equivalent qualifications will be preferentially considered.
Please submit your application by email with the usual documents (cover letter, CV, three references,
Master’s transcript, Ph.D. certificate if applicable) to:
Prof. Tobias Langenhan
Faculty of Medicine
Rudolf Schönheimer Institute of Biochemistry
Division of General Biochemistry
E: jobs ÄT langenhan-lab.org
Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
Scholz N*,#, Dahse A-K*, Kemkemer M, Bormann A, Auger GM, Contreras FV, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T#
7TM domain structures of adhesion GPCRs: what’s new and what’s missing?
Trends in Biochemical Sciences
Seufert F*, Chung YK*, Hildebrand PW#, Langenhan T#
Improving one-step scarless genome editing in
Drosophila melanogaster by combining ovoD co-CRISPR selection with sgRNA target site masking
Biology Methods & Protocols
Götze KJ*, Mrestani A*, Beckmann P, Krohn K, Le Duc D, Velluva A, Böhme MA, Heckmann M, Abou Jamra R, Lemke JR, Bläker H, Scholz N, Ljaschenko D#, Langenhan T#
The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release
Paul MM*, Dannhäuser S*, Morris L*, Mrestani A*, Hübsch M, Gehring J, Hatzopoulos GN, Pauli M, Auger GM, Bornschein G, Scholz N, Ljaschenko D, Müller M, Sauer M, Schmidt H, Kittel RJ, DiAntonio A, Vakonakis I, Heckmann M#, Langenhan T#
Altered gene expression profiles impair the nervous system development in individuals with 15q13.3 microdeletion
Körner MB*, Velluva A*, Bundalian L, Radtke M, Lin CC, Zacher P, Bartolomaeus T, Kirstein AS, Mrestani A, Scholz N, Platzer K, Teichmann AC, Hentschel J, Langenhan T, Lemke JR, Garten A, Abou Jamra R#, Le Duc D#
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain
Beliu G*, Altrichter S*, Guixà-González R*, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW#, Sauer M#, Langenhan T#
Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila
Journal of Experimental Biology
Blanco-Redondo B#, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E#
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
Hamann J*,#, Aust G*, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T*, Schiöth HB*,#
New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors
Annals of the New York Academy of Sciences
Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X
Dissecting signaling and functions of adhesion G protein-coupled receptors
Annals of the New York Academy of Sciences
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T
Rudolf Schönheimer Institute of Biochemistry
Division of General Biochemistry. Medical Faculty. Leipzig University
Johannisallee 30. 04103 Leipzig. Germany
Phone: +49 (0) 341 97-22100
tobi ÄT langenhan-lab.org