langenhan

lab

leipzig

 

science.

We study the molecular logic of adhesion GPCRs in health and disease.

We investigate molecular actors that belong to the class of adhesion-type G protein-coupled receptors. These molecules form a large group of surface receptors that constitute natural chimeras between an extracellular adhesion moiety and a transmembrane metabotropic signalling unit.

 

We have discovered that specific adhesion GPCRs control developmental processes such as planar cell polarity and cell migration, and have contributed to the understanding how adhesion and signalling is functionally combined within these mysterious surface receptors.

Recently we have defined adhesion GPCRs as mechanoreceptors suggesting a novel scientific angle to study and understand their physiological profiles in a multitude of tissues and cell types including neurons, glia, muscle, vasculature and the heart.

 

We are also harnessing our knowledge to understand how adhesion GPCR dysfunction results in disease with focus on cancers and neuropsychiatric disorders. To this end we closely collaborate with clinician scientists and human geneticists to identify adhesion GPCR gene variants that cause human ailments.

We study these phenomena using the fruitfly Drosophila melanogaster and the the roundworm Caenorhabditis elegans and employ their vast genetic, molecular biological, imaging and functional toolkits. This is complemented by in vitro and in silico approaches encompassing molecular modifications through genetic code expansion and bioorthogonal click chemistry, pharmacological and cell biological assays, super-resolution and atomic force microscopy, structural biology, and molecular dynamics simulations.

 

people.

Lena Abicht

Technician

lena.abicht@medizin.uni-leipzig.de

Genevieve Auger

PhD Candidate

genevieve.auger@medizin.uni-leipzig.de

Marina Bigl, PhD

Group Leader

marina.bigl@medizin.uni-leipzig.de

Beatriz Blanco-Redondo, PhD

Group Leader

beatriz.blanco-redondo@medizin.uni-leipzig.de

Andrea Böhme

Technician

andrea.boehme@medizin.uni-leipzig.de

Ina Brauer

PhD Candidate

ina.brauer@medizin.uni-leipzig.de

Fernando Vieira Contreras

PhD Candidate

fernando.vieiracontreras@medizin.uni-leipzig.de

Anne Dahse

PhD Candidate

anne.dahse@medizin.uni-leipzig.de

Carlo Eberlein

BSc Candidate

ce86gawy@studserv.uni-leipzig.de

Kerstin Heise

Technician

kerstin.heise@medizin.uni-leipzig.de

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Katharina Götze

MD Candidate

katharina.goetze@medizin.uni-leipzig.de

Mareike Hemberger

PhD Candidate

mareike.hemberger@medizin.uni-leipzig.de

Marek Körner

MSc Candidate

mk41fyki@studserv.uni-leipzig.de

Head of Department

tobi@langenhan-lab.org

Dmitrij Ljaschenko, PhD

Group Leader

dmitrij.ljaschenko@medizin.uni-leipzig.de

Bianca Löffler

Secretary

bianca.loeffler@medizin.uni-leipzig.de

Lena Müller

MSc Candidate

tlm77fiwo@studserv.uni-leipzig.de

Nicole Scholz, PhD

Group Leader

scholzlab@gmail.com

Hauke Staake

MD Candidate

katharina.goetze@medizin.uni-leipzig.de

Frank Struck

Technician

frank.struck@medizin.uni-leipzig.de

Robert Wieduwild, PhD

Group Leader

robert.wieduwild@medizin.uni-leipzig.de

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ALUMNI

Robin Fischer, PhD

Diploma Student (Biology) (2010-2011)

Jennifer Gehring, PhD

Diploma (Biology) and PhD Student (2010-2014)

Chonglin Guan, PhD

PhD Student (2012-2017)

Maria Oppmann

Technician (2009-2016)

Samuel Widmann

Technician (2018)

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Matthias Nieberler, MD

MD Student (2013-2018)

Angelika Schäfer

Technician (2016-2018)

Lydia Morris, MSc

Erasmus Student (Cardiff University) (2017-2018)

Johanna Irmer, MSc

MSc Student (2018)

Steffen Altrichter, PhD

PhD Student (2015-2020)

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events.

 jobs. 

We are eager to take on new lab members at different stages in their career starting from lab interns, students striving for their bachelor and master projects, M.D. and Ph.D. candidates, as well as postdoctoral researchers.

 

If you are interested in joining our research party get in touch at

tobi ÄT langenhan-lab.org with your motivation, project ideas and transcripts.

 

READY FOR A FUN AND

AMBITIOUS PHD PROJECT?

What?

Several fixed-term for 3 years PhD positions are open at the Langenhan Lab based at the University of Leipzig. The successful candidates will work at the interface between molecular pharmacology, physiology and biophysics in a project of the Rudolf Schönheimer Institute for Biochemistry.

Scientific goal?

The projects concern the investigation of novel class of surface receptor molecules that function as mechanosensors and are markers of cancer progression. 

Central questions concern the fundamental physiological tasks, pharmacological principles and viscoelastic properties of these receptors and their expressing cells and tissues. The main objective is the determination how these receptors’ activation and signaling mechanism is implemented at the molecular and cellular scale. The projects will rest on the close collaboration between biomedical researchers, structural biologists and physicists. The experimental measurements will be facilitated by in-house theoretical and experimental support.

The successful candidates will establish structure-function studies and pharmacological signaling assays of receptor activity, and combine those with biophysical measurements, genetic, biofinformatical and physiological assays using Drosophila melanogaster as an in vivo model for adhesion GPCR signaling.

Who are you?

The candidates should have a MSc. degree in physics, material science, biology or related fields, be fluent in English and have solid background in physics or molecular biology. Experience with the investigation of biomolecules with physical methods (e.g. AFM-FS, magnetic or optical tweezers), molecular biology or Drosophila is beneficial but not mandatory.

POSTDOCTORAL RESEARCH ASSOCIATE

OR GROUP LEADER POSITION

What?

Applications are sought from strong candidates working in any area of biomedicine that complements or builds upon existing research strengths in the department. This search is open, but preference is given to those applicants with experience in neurobiology, molecular pharmacology or biochemistry holding or seeking their own post-doctoral fellowship.

Scientific goal?

This is for you to define. We'll help and advise you to get you started,

build up your own team, procure funding and excel with your research ideas.

Who are you?

Candidates must hold a Doctorate in a biological subject (ideally medicine, biology, bioinformatics, or biochemistry). Candidates are given the opportunity to establish their own research program, and assistance will be available to attract the necessary funding for the successful applicant.

Who are we?

The PhD students will have access to state-of-the-art laboratories, which are located at the Institute of Biochemistry and partner institutions in Leipzig. The international and interdisciplinary environment at the department provides an excellent infrastructure allowing dynamic scientific exchange across the traditional disciplines. The lab has also a central role in the German (www.adhesiongpcr.de) and international adhesion GPCR communities (www.adhesiongpcr.org) and successful candidates will gain immediate access to a young yet rapidly emerging field in biomedicine with substantial long-term career potential.

Where?

Leipzig is a pretty sassy place to be at in Germany, of not the trendiest ... say not only we but also the New York Times, The Guardian, Der Spiegel, and others.

In addition, Leipzig University is an equal opportunity employer and is committed to increase the proportion of women in academia. Consequently, we actively encourage applications by female colleagues. Female candidates with equivalent qualifications and academic achievements will be preferentially considered within the framework of the legal possibilities. We also welcome applications from candidates with severe disabilities. Disabled candidates with equivalent qualifications will be preferentially considered.


 

How?
Please submit your application by email with the usual documents (cover letter, CV, three references,

Master’s transcript, Ph.D. certificate if applicable) to:​

Prof. Tobias Langenhan

Faculty of Medicine

Rudolf Schönheimer Institute of Biochemistry

Division of General Biochemistry

Leipzig University

E: jobs ÄT langenhan-lab.org​

 

publications.

Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

The concise guide to pharmacology 2019/20: G protein-coupled receptors

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila

Blanco-Redondo B#, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E#

Journal of Experimental Biology 222: jeb203505

2019

Revisiting the classification of adhesion GPCRs

Scholz N, Langenhan T*,#, Schöneberg T*,#

Annals of the New York Academy of Sciences 1456: 80-95

2019

Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets

Langenhan T

Basic & Clinical Pharmacology & Toxicology 547: 145

2018

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix

Scholz N*, Ehmann N*, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Pauli M, Heckmann M, Stigloher C, Langenhan T#, Kittel RJ#

Journal of Cell Biology 218: 1011-1026

2019

Parallel genomic engineering of two Drosophila genes using orthogonal attB/attP sites

Blanco-Redondo B,Langenhan T

G3: Genes, Genomes, Genetics 8: 3109-3118

2018

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

Scholz N*, Guan C*, Nieberler M*, Grotemeyer A*, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T#, Kittel RJ#

eLife 6: e28360

2017

See also Insight article by Wayne A Johnson. Mechanotransduction: Two views of the same stimulus.