langenhan

lab

leipzig

 

science.

We study the molecular logic of adhesion GPCRs in health and disease.

We investigate molecular actors that belong to the class of adhesion-type G protein-coupled receptors. These molecules form a large group of surface receptors that constitute natural chimeras between an extracellular adhesion moiety and a transmembrane metabotropic signalling unit.

 

We have discovered that specific adhesion GPCRs control developmental processes such as planar cell polarity and cell migration, and have contributed to the understanding how adhesion and signalling is functionally combined within these mysterious surface receptors.

Recently we have defined adhesion GPCRs as mechanoreceptors suggesting a novel scientific angle to study and understand their physiological profiles in a multitude of tissues and cell types including neurons, glia, muscle, vasculature and the heart.

 

We are also harnessing our knowledge to understand how adhesion GPCR dysfunction results in disease with focus on cancers and neuropsychiatric disorders. To this end we closely collaborate with clinician scientists and human geneticists to identify adhesion GPCR gene variants that cause human ailments.

We study these phenomena using the fruitfly Drosophila melanogaster and the the roundworm Caenorhabditis elegans and employ their vast genetic, molecular biological, imaging and functional toolkits. This is complemented by in vitro and in silico approaches encompassing molecular modifications through genetic code expansion and bioorthogonal click chemistry, pharmacological and cell biological assays, super-resolution and atomic force microscopy, structural biology, and molecular dynamics simulations.

 

people.

Sophia Schmidt

Student assistant

Joris Lehmann, BSc

MSc candidate

Hauke Staake

MD candidate

Tobias Langenhan, MD, DPhil

Head of Department

Kerstin Heise

Technician

Andrea Böhme

Technician

Paula Beckmann, MSc

Technician

Carlo Eberlein, BSc

Student assistant

Nicole Scholz, PhD

Group leader

Marek Körner, MSc

PhD candidate

Anne Dahse, MSc

PhD candidate

Beatriz Blanco-Redondo, PhD

Group leader

Marie Gläser

MD candidate

Lena Abicht

Student assistant

Bianca Löffler

Secretary

Mareike Hemberger, MSc

PhD candidate

Fernando Vieira Contreras, MSc

PhD candidate

Marina Bigl, PhD

Group leader

Anne Bormann, MSc

PhD candidate

Frank Struck

Technician

Dmitrij Ljaschenko, PhD

Group leader

Katharina Götze

MD candidate

Ina Brauer, MSc

PhD candidate

Genevieve Auger, MSc

PhD candidate

ALUMNI

Lena Müller

BSc Student (2018) and MSc Student (2019-2020)

Lydia Morris

Erasmus Student, Cardiff University (2017-2018)

Maria Oppmann

Technician (2009-2016)

Robert Wieduwild, PhD

Group Leader (2018-2020)

Angelika Schäfer

Technician (2016-2018)

Chonglin Guan, PhD

PhD Student (2012-2017)

Steffen Altrichter, PhD

PhD Student (2015-2020)

Matthias Nieberler, MD

MD Student (2013-2018)

Jennifer Gehring, PhD

Diploma (Biology) and PhD Student (2010-2014)

Johanna Irmer

MSc Student (2018)

Samuel Widmann

Technician (2018)

Robin Fischer, PhD

Diploma Student (Biology) (2010-2011)

 

events.

 jobs. 

We are eager to take on new lab members at different stages in their career starting from lab interns, students striving for their bachelor and master projects, M.D. and Ph.D. candidates, as well as postdoctoral researchers.

 

If you are interested in joining our research party get in touch at

tobi ÄT langenhan-lab.org with your motivation, project ideas and transcripts.

 

READY FOR A FUN AND

AMBITIOUS PHD PROJECT?

What?

Several fixed-term for 3 years PhD positions are open at the Langenhan Lab based at the University of Leipzig. The successful candidates will work at the interface between molecular pharmacology, physiology and biophysics in a project of the Rudolf Schönheimer Institute for Biochemistry.

Scientific goal?

The projects concern the investigation of novel class of surface receptor molecules that function as mechanosensors and are markers of cancer progression. 

Central questions concern the fundamental physiological tasks, pharmacological principles and viscoelastic properties of these receptors and their expressing cells and tissues. The main objective is the determination how these receptors’ activation and signaling mechanism is implemented at the molecular and cellular scale. The projects will rest on the close collaboration between biomedical researchers, structural biologists and physicists. The experimental measurements will be facilitated by in-house theoretical and experimental support.

The successful candidates will establish structure-function studies and pharmacological signaling assays of receptor activity, and combine those with biophysical measurements, genetic, biofinformatical and physiological assays using Drosophila melanogaster as an in vivo model for adhesion GPCR signaling.

Who are you?

The candidates should have a MSc. degree in physics, material science, biology or related fields, be fluent in English and have solid background in physics or molecular biology. Experience with the investigation of biomolecules with physical methods (e.g. AFM-FS, magnetic or optical tweezers), molecular biology or Drosophila is beneficial but not mandatory.

POSTDOCTORAL RESEARCH ASSOCIATE

OR GROUP LEADER POSITION

What?

Applications are sought from strong candidates working in any area of biomedicine that complements or builds upon existing research strengths in the department. This search is open, but preference is given to those applicants with experience in neurobiology, molecular pharmacology or biochemistry holding or seeking their own post-doctoral fellowship.

Scientific goal?

This is for you to define. We'll help and advise you to get you started,

build up your own team, procure funding and excel with your research ideas.

Who are you?

Candidates must hold a Doctorate in a biological subject (ideally medicine, biology, bioinformatics, or biochemistry). Candidates are given the opportunity to establish their own research program, and assistance will be available to attract the necessary funding for the successful applicant.

Who are we?

The PhD students will have access to state-of-the-art laboratories, which are located at the Institute of Biochemistry and partner institutions in Leipzig. The international and interdisciplinary environment at the department provides an excellent infrastructure allowing dynamic scientific exchange across the traditional disciplines. The lab has also a central role in the German (www.adhesiongpcr.de) and international adhesion GPCR communities (www.adhesiongpcr.org) and successful candidates will gain immediate access to a young yet rapidly emerging field in biomedicine with substantial long-term career potential.

Where?

Leipzig is a pretty sassy place to be at in Germany, of not the trendiest ... say not only we but also the New York Times, The Guardian, Der Spiegel, and others.

In addition, Leipzig University is an equal opportunity employer and is committed to increase the proportion of women in academia. Consequently, we actively encourage applications by female colleagues. Female candidates with equivalent qualifications and academic achievements will be preferentially considered within the framework of the legal possibilities. We also welcome applications from candidates with severe disabilities. Disabled candidates with equivalent qualifications will be preferentially considered.


 

How?
Please submit your application by email with the usual documents (cover letter, CV, three references,

Master’s transcript, Ph.D. certificate if applicable) to:​

Prof. Tobias Langenhan

Faculty of Medicine

Rudolf Schönheimer Institute of Biochemistry

Division of General Biochemistry

Leipzig University

E: jobs ÄT langenhan-lab.org​

 

publications.

Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination

2020

eLife

9: e56738

Dannhäuser S, Lux TJ, Hu C, Selcho M, Chen JT, Ehmann N, Sachidanandan, Stopp S, Pauls D, Pawlak M, Langenhan T, Soba P, Rittner HL, Kittel RJ

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

2020

Nature Chemical Biology

58: 429

Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N,Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA

The concise guide to pharmacology 2019/20: G protein-coupled receptors

2019

British Journal of Pharmacology

176 Suppl 1: S21-S141

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila

2019

Journal of Experimental Biology

222: jeb203505

Blanco-Redondo B#, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E#

Revisiting the classification of adhesion GPCRs

2019

Annals of the New York Academy of Sciences

1456: 80-95

Scholz N, Langenhan T*,#, Schöneberg T*,#

Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets

2019

Basic & Clinical Pharmacology & Toxicology

547: 145

Langenhan T

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix

2019

Journal of Cell Biology

218: 1011-1026

Scholz N*, Ehmann N*, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Pauli M, Heckmann M, Stigloher C, Langenhan T#, Kittel RJ#

Parallel genomic engineering of two Drosophila genes using orthogonal attB/attP sites

2018

G3: Genes, Genomes, Genetics

8: 3109-3118

Blanco-Redondo B,Langenhan T

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

2017

eLife

6: e28360

Scholz N*, Guan C*, Nieberler M*, Grotemeyer A*, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T#, Kittel RJ#

Adhesion G protein-coupled receptors in nervous system development and disease

2016

Nature Reviews Neuroscience

17:550-561

Langenhan T#, Piao X#, Monk KR#

Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors

2016

Handbook Experimental Pharmacology

234: 221-247

Scholz N#, Monk KR, Kittel RJ, Langenhan T#

Control of Adhesion GPCR Function Through Proteolytic Processing

2016

Handbook Experimental Pharmacology

234: 83-109

Nieberler M, Kittel RJ, Petrenko AG, Lin HH#, Langenhan T#

Effects of transgenic expression of botulinum toxins in Drosophila

2016

Journal of Neurogenetics

30:22-31

Backhaus P, Langenhan T, Neuser K

The Adhesion GPCR Latrophilin/CIRL shapes mechanosensation

2015

Cell Reports

11:866-874

Scholz N*, Gehring J*, Guan C*, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T#

Model organisms in G protein–coupled receptor research

2015

Molecular Pharmacology

88:596-603

Langenhan T#, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR#

Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms

2015

Molecular Pharmacology

88:617-623

Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

2015

Pharmacological Reviews

67(2):338-367

Hamann J*,#, Aust G*, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T*, Schiöth HB*,#

Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications

2014

Proceedings of the National Academy of Sciences of the USA

111(38):13972-7

Dawydow A*, Gueta R*, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G#, Kittel RJ#

New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors

2014

Annals of the New York Academy of Sciences

1333(1):43-64

Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X

Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins

2013

Trends in Pharmacological Sciences

34 (8):470-478

Prömel S†, Langenhan T†,#, Araç D†,#

Sticky Signaling — Adhesion Class G Protein–Coupled Receptors Take the Stage

2013

Science Signaling

6 (276):re3

Langenhan T*,#, Aust G*, Hamann J*

Dissecting signaling and functions of adhesion G protein-coupled receptors

2012

Annals of the New York Academy of Sciences

1276 (1):1-25

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T

Adhäsions-G-Protein-gekoppelte Rezeptoren — rätselhafte Riesen

2013

Biospektrum

19 (7):717-719

Prömel S, Aust G, Langenhan T, Schöneberg T

The GPS motif is a molecular switch for bimodal activities of Adhesion-class G protein-coupled receptors

2012

Cell Reports

2 (2):321-331

Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP*, Langenhan T*,#

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCRs in mouse

2012

Developmental Dynamics

241 (10):1591-1602

Prömel S#, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T#

Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP

2010

PLoS One

5 (11):e14047

Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP

Latrophilin signalling in tissue polarity and morphogenesis

2010

Advances in Experimental Medicine and Biology

706:37-48

Langenhan T#, Russ AP#

Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency

2010

Neuron

68 (6):1109–1127

McGuinness L, Taylor C, Taylor RDT, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ

Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo

2009

Developmental Cell

17 (4):494-504

Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP

Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain

2008

Structure

16 (6):944-953

Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID

Ciliary neurotrophic factor (CNTF) in the olfactory system of rats and mice

2006

Annals of Anatomy

188 (5):411–413

Langenhan T

Ciliary neurotrophic factor-immunoreactivity in olfactory sensory neurons

2005

Neuroscience

134 (4):1179–1194

Langenhan T, Sendtner M, Holtmann B, Carroll P, Asan E

Ciliary neurotrophic factor in the olfactory bulb of rats and mice

2003

Neuroscience

120 (1):99–112

Asan E, Langenhan T, Holtmann B, Bock H, Sendtner M, Carroll P

 

contact.

Tobi Langenhan

Rudolf Schönheimer Institute of Biochemistry

Division of General Biochemistry. Medical Faculty. Leipzig University

Johannisallee 30. 04103 Leipzig. Germany

Phone: +49 (0) 341 97-22100

tobi ÄT langenhan-lab.org